Scientific Publications

CBLI Publications

• Burdelya LG, Krivokrysenko VI, Tallant TC, Strom E, Gleiberman AS, Gupta D, Kurnasov OV, Fort FL, Osterman AL, DiDonato JA, Feinstein E, Gudkov AV.
  
  An Agonist of Toll-like Receptor 5 Has Radioprotective Activity in Mouse and Primate Models. Science Magazine, 2008 April 11; 320: 226-230.
  


• Strom E, Sathe S, Komarov PG, Chernova OB, Pavlovska I, Shyshynova I, Bosykh DA, Burdelya LG, Macklis RM, Skaliter R, Komarova EA, Gudkov AV.
  
  Small molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation. Nature Chemical Biology, 2006 July 23; 2(7): 1-5.
  
  
• Boiko AD, Porteous S, Razorenova OV, Krivokrysenko VI, Williams BR, Gudkov AV.
  
  A systematic search for downstream mediators of tumor suppressor function of p53 reveals a major role of BTG2 in suppression of Ras-induced transformation. Genes & Development, 2006 Jan. 1; 20(2): 236-52.
  
  
• Gurova KV, Hill JE, Guo C, Prokvolit A, Burdelya LG, Samoylova E, Khodyakova AV,Ganapathi R, Ganapathi M, Tararova ND, Bosykh D, Lvovskiy D, Webb TR, Stark GR, Gudkov AV.
  
  Small molecules that reactivate p53 in renal cell carcinoma reveal a NF-kappaB-dependent mechanism of p53 suppression in tumors. Proc Natl Acad Sci U S A., 2005 Nov 29; 102(48):17448-53.
  
  
• Komarova EA, Krivokrysenko V, Wang K, Neznanov N, Chernov MV, Komarov PG, Brennan ML, Golovkina TV, Rokhlin OW, Kuprash DV, Nedospasov SA, Hazen SL, Feinstein E, Gudkov AV.
  
  p53 is a suppressor of inflammatory response in mice. FASEB Journal, 2005 Jun; 19(8):1030-2.
  
  
• Gudkov AV, Komarova EA.
  
  Prospective therapeutic applications of p53 inhibitors. Biochemical and Biophysical Research Communications, 2005 Apr 2; 331(1): 726-736.
  
  

Other Publications (Supporting CBLI Technology)

• Komarova EA, Kondratov RV, Wang K, Christov K, Golovkina TV, Goldblum JR, Gudkov AV.
  
  Dual effect of p53 on radiation sensitivity in vivo: p53 promotes hematopoietic injury, but protects from gastro-intestinal syndrome in mice. Oncogene, 2004 Apr 5; 23(2): 3265-3271.
  
  
• Komarov PG, Komarova EA, Kondratov RV, Christov-Tselkov K, Coon JS, Chernov MV,Gudkov AV.
  
  A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. Science, 1999 Sept 10; 285(2): 1733-1737.
  

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