CBLB612, a clinical-stage investigational drug, is a synthetic lipopeptide. CBLB612 activates NF-kB pro-survival and immunoregulatory signaling pathways via specific binding to toll-like receptor 2 (TLR2) on a subset of body tissues and cell types that express this receptor.
Preclinical studies have shown that CBLB612 stimulates white blood cell regeneration. More recent research indicates that stimulation of these toll-like receptors may also enhance anti-tumor efficacy. We believe an opportunity may exist for CBLB612 to offer a single-dose alternative to existing hemopoietic growth factors.
A Phase 1, single-center, blind, placebo-controlled, single ascending-dose study to evaluate the safety, tolerability, and pharmacodynamic effects of CBLB612 in healthy volunteers was completed in the Russian Federation.
A Phase 2, randomized, placebo-controlled clinical study of CBLB612 as myelosuppressive prophylaxis in patients with breast cancer receiving doxorubicin-cyclophosphamide chemotherapy was initiated in the Russian Federation.
Cleveland BioLabs, Inc.
73 High Street
Buffalo, NY 14203
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Intellectual Property Rights
Certain Site Content
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This Site contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements reflect management’s current expectations, as of the date of this press release, and involve certain risks and uncertainties. The Company’s actual results could differ materially from those anticipated in these forward-looking statements as a result of various factors.
These factors include, among others, the Company’s history of operating losses and the potential for future losses, which may lead the Company to not be able to continue as a going concern; the Company’s need for substantial additional financing to meet its business objectives; the potential for the loss of funding from the Company’s R&D grants and contracts and its ability to win additional funding under such grants and contracts; the Company’s failure to successfully and timely develop new products; the risks inherent in the early stages of drug development and in conducting clinical trials; the Company’s inability to obtain regulatory approval in a timely manner or at all; the Company’s collaborative relationships and the financial risks related thereto; the Company’s ability to comply with its obligations under license agreements; the potential for significant product liability claims; and the Company’s ability to comply with various safety, environmental and other governmental regulations. Some of these factors could cause future results to materially differ from the recent results or those projected in forward-looking statements. See also the “Risk Factors” and “Forward-Looking Statements” described in the Company’s periodic filings with the Securities and Exchange Commission.
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The Site may provide hypertext links to other web sites that are not owned or controlled by Cleveland BioLabs. These links are provided for your convenience only. These web sites are controlled by third parties that Cleveland BioLabs does not control. Accordingly, Cleveland BioLabs expressly disclaims any responsibility for the content of such web sites, for the accuracy or reliability of the information thereon and for the quality of products or services provided thereby or advertised thereon. No link included on the Site constitutes an endorsement of Cleveland BioLabs of any content of, information on or product or service provided by, or advertised on, any such web site. If you choose to hyperlink to another web site, you do so at your own risk. Cleveland BioLabs reserves the right to terminate any hypertext link without notice.
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Collection of Personal Information
We collect Personal Information that you submit to us voluntarily through our website. The types of Information we collect are:
For visitors who email us directly via an email hyperlink:
- Email address
- Any content included in the email
For all visitors:
- As you navigate our website, certain passive information will also be collected, including Internet Protocol addresses, cookies and navigational data. This type of information will be used for the purposes of gathering data to provide improved administration of our website, and to improve the quality of your experience when interacting with our website.
Use of Personal Information
In general, Personal Information you submit to us is used either to respond to requests that you make, or to aid us in serving you better.
Disclosure of Personal Information
We do not sell your Personal Information or share your information with other companies or organizations without your consent. The content of any communications you send to us is non-confidential, and we are under no obligation to refrain from reproducing, publishing, or otherwise using such content in any way or for any purpose. We will not reproduce, publish, or otherwise use your Personal Information in connection with such content. We may, however, reproduce or use your Personal Information in connection with any resume you submit to us for employment recruiting purposes. We are free to use the content of any such communications (excluding any resume you submit to us), including any ideas, inventions, concepts, techniques, or know-how disclosed therein, for any purpose including developing, manufacturing, and/or marketing goods or services.
Our website is not designed for children under the age of 13. We will not deliberately gather Personal Information about visitors in this age group, and do not collect any information on this website with respect to age.
Links to Other Sites
Cleveland BioLabs, Inc.
73 High St.
Buffalo, NY 14203
This policy was last updated on June 15, 2012.