CBLI Publications
• Neznanov N, Gorbachev AA, Neznanova L, Komarov AP, Gurova KV, Gasparian AV, Banerjee AK, Almasan A, Fairchild RL, Gudkov AV
Anti-malaria drug blocks proteotoxic stress response. Cell Cycle 2009 December 1; 8:23, 1-11
• Guo C, Gasparian AV, Zhuang Z, Bosykh DA, Komar AA, Gudkov AV, Gurova,KV.
9 Aminoacridine-based anticancer drugs target the PI3K/AKT/mTOR, NF-kappaB and p53 pathways. Oncogene 2009 January 12; 28:1151–1161.
• Burdelya LG, Krivokrysenko VI, Tallant TC, Strom E, Gleiberman
AS, Gupta D, Kurnasov OV, Fort FL, Osterman AL, DiDonato JA, Feinstein
E, Gudkov AV.
An
Agonist of Toll-like Receptor 5 Has Radioprotective Activity in
Mouse and Primate Models. Science Magazine, 2008 April 11; 320:
226-230.
• Strom E, Sathe S, Komarov PG, Chernova OB, Pavlovska I, Shyshynova
I, Bosykh DA, Burdelya LG, Macklis RM, Skaliter R, Komarova EA,
Gudkov AV.
Small
molecule inhibitor of p53 binding to mitochondria protects mice
from gamma radiation. Nature Chemical Biology, 2006 July 23; 2(7):
1-5.
• Boiko AD, Porteous S, Razorenova OV, Krivokrysenko VI, Williams
BR, Gudkov AV.
A systematic search for downstream mediators of tumor suppressor
function of p53 reveals a major role of BTG2 in suppression of
Ras-induced transformation. Genes & Development, 2006 Jan.
1; 20(2):236-52.
• Gurova KV, Hill JE, Guo C, Prokvolit A, Burdelya LG, Samoylova
E, Khodyakova AV,Ganapathi R, Ganapathi M, Tararova ND, Bosykh
D, Lvovskiy D, Webb TR, Stark GR, Gudkov AV.
Small molecules that reactivate p53 in
renal cell carcinoma reveal a NF-kappaB-dependent mechanism of
p53 suppression in tumors. Proc Natl Acad Sci U S A., 2005 Nov
29;102(48):17448-53.
• Komarova EA, Krivokrysenko V, Wang K, Neznanov N, Chernov MV,
Komarov PG, Brennan ML, Golovkina TV, Rokhlin OW, Kuprash DV,
Nedospasov SA, Hazen SL, Feinstein E, Gudkov AV.
p53 is a suppressor of inflammatory response
in mice. FASEB Journal, 2005 Jun; 19(8):1030-2.
• Gudkov AV, Komarova EA.
Prospective
therapeutic applications of p53 inhibitors. Biochemical and Biophysical
Research Communications, 2005 Apr 2; 331(1): 726-736.
Other Publications (Supporting CBLI Technology)
• Komarova EA, Kondratov RV, Wang K, Christov K, Golovkina TV,
Goldblum JR, Gudkov AV.
Dual effect of p53 on radiation sensitivity
in vivo: p53 promotes hematopoietic injury, but protects from
gastro-intestinal syndrome in mice. Oncogene, 2004 Apr 5; 23(2):
3265-3271.
• Komarov PG, Komarova EA, Kondratov RV, Christov-Tselkov K, Coon
JS, Chernov MV,Gudkov AV.
A chemical inhibitor of p53 that protects mice from the side effects
of cancer therapy. Science, 1999 Sept 10; 285(2): 1733-1737.
